2023, Vol: 3
3Current Volume Online FirstArchiveAims and ScopeAbstracting & IndexingMost Accessed ArticlesMost Downloaded ArticlesMost Cited Articles

Review Article 


A note on the current status of the trans ungual drug delivery system at a glance

Srinivas Bhairy, Alfiha Momin, Mugdha Pednekar, Devendra Madan, Ashraf Shaikh, Rahul Bankar, Subrahmanyam Pitchika.

Abstract
The Trans ungual drug delivery (TUDD) system involves the delivery of drugs through the hard keratinized nail plate. Topical treatment is ideal for treating nail diseases because it has localized effects, resulting in fewer systemic side effects and perhaps better adherence. Conventional formulations have failed to promote nail adhesion and medication absorption due to the nail's highly keratinized hydrophilic nature, which obstructs drug absorption. Systemic therapy has substantial adverse effects and a high rate of recurrence, whereas surgery is painful and invasive. As a result, there is a definite need to design an efficient TUDD system that allows antifungals to penetrate the nail and reach the infection site at a sufficient concentration and for a longer period of action to eliminate the infection. The system also avoids the oral toxicity of drugs. Several techniques, including physical, chemical, and mechanical, are employed to increase medication penetration over the nail plate. However, the nail remains a barrier to providing a complete cure. To increase nail adherence, therapeutic action, and bioavailability, several innovative formulation techniques are being researched, including the use of penetration enhancers in traditional dosage forms (gel, solution), novel dosage forms such as films, nail lacquer, and nanotechnology.

Key words: Trans ungual drug delivery, Human nail, Anti-fungal, Permeation, Novel formulations, Nanotechnology, Bioavailability


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Srinivas Bhairy
Articles by Alfiha Momin
Articles by Mugdha Pednekar
Articles by Devendra Madan
Articles by Ashraf Shaikh
Articles by Rahul Bankar
Articles by Subrahmanyam Pitchika
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Bhairy S, Momin A, Pednekar M, Madan D, Shaikh A, Bankar R, Pitchika S. A note on the current status of the trans ungual drug delivery system at a glance. DSP. 2023; 3(0): 1-14.

Web Style

Bhairy S, Momin A, Pednekar M, Madan D, Shaikh A, Bankar R, Pitchika S. A note on the current status of the trans ungual drug delivery system at a glance. https://www.journaldsp.com/?mno=45605 [Access: December 05, 2023].

AMA (American Medical Association) Style

Bhairy S, Momin A, Pednekar M, Madan D, Shaikh A, Bankar R, Pitchika S. A note on the current status of the trans ungual drug delivery system at a glance. DSP. 2023; 3(0): 1-14.


Vancouver/ICMJE Style

Bhairy S, Momin A, Pednekar M, Madan D, Shaikh A, Bankar R, Pitchika S. A note on the current status of the trans ungual drug delivery system at a glance. DSP. (2023), [cited December 05, 2023]; 3(0): 1-14.


Harvard Style

Bhairy, S., Momin, . A., Pednekar, . M., Madan, . D., Shaikh, . A., Bankar, . R. & Pitchika, . S. (2023) A note on the current status of the trans ungual drug delivery system at a glance. DSP, 3 (0), 1-14.


Turabian Style

Bhairy, Srinivas, Alfiha Momin, Mugdha Pednekar, Devendra Madan, Ashraf Shaikh, Rahul Bankar, and Subrahmanyam Pitchika. 2023. A note on the current status of the trans ungual drug delivery system at a glance. DRUG SCIENCE & PHARMACY, 3 (0), 1-14.


Chicago Style

Bhairy, Srinivas, Alfiha Momin, Mugdha Pednekar, Devendra Madan, Ashraf Shaikh, Rahul Bankar, and Subrahmanyam Pitchika. "A note on the current status of the trans ungual drug delivery system at a glance." DRUG SCIENCE & PHARMACY 3 (2023), 1-14.


MLA (The Modern Language Association) Style

Bhairy, Srinivas, Alfiha Momin, Mugdha Pednekar, Devendra Madan, Ashraf Shaikh, Rahul Bankar, and Subrahmanyam Pitchika. "A note on the current status of the trans ungual drug delivery system at a glance." DRUG SCIENCE & PHARMACY 3.0 (2023), 1-14. Print.


APA (American Psychological Association) Style

Bhairy, S., Momin, . A., Pednekar, . M., Madan, . D., Shaikh, . A., Bankar, . R. & Pitchika, . S. (2023) A note on the current status of the trans ungual drug delivery system at a glance. DRUG SCIENCE & PHARMACY, 3 (0), 1-14.


Author LoginReviewer LoginAbout PublisherEditorial PoliciesPeer Review PolicyPublication Ethics and Publication Malpractice StatementPlagiarism PolicyProtection of Research Participants (Statement On Human And Animal Rights)Privacy PolicyCorrections, Retractions & Expressions of ConcernSelf-Archiving PoliciesTerms of Use

About DRUG SCIENCE & PHARMACY

ABOUT JOURNAL An international, peer-reviewed, open access journal that spans the spectrum of drug, science and pharmacy including drug design and deve ... Read more.



For best results, please use Internet Explorer or Google Chrome.

Contact Information


Editor-in-Chief

Drug Science & Pharmacy (DSP)

Email: eicdsp@gmail.com